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Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese
Chen-Hui Luo1, An Wang, Rong-Hua Zhu
1Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, China.
Aims:
To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese.
Methods:
Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6.
Results:
CYP2C9*6 was not detected in this study. The allelic frequency of CYP2C9*3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9*3 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9*3 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476).
Conclusions:
The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.
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