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Tissue typing for hematopoietic cell transplantation: newer techniques and newer antigens for which cross-matching is

Robert Iannone1, Stella M Davies

  • 1Children's Hospital of Philadelphia and University of Pennsyvania, Philadelphia, PA, USA.

Pediatric Transplantation
|November 25, 2005
PubMed

Refinements in human leukocyte antigen (HLA) typing techniques for hematopoietic cell transplantation (HCT) have permitted a more precise assessment of donor-recipient histocompatibility, which has impacted transplantation outcomes. More recently, differences in transplant outcomes associated with killer immunoglobulin-like receptor compatibility have emphasized the potential importance of natural killer (NK) cell typing in HCT. This article reviews the current state of the art for HCT donor selection based on both HLA and NK cell typing.

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