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Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy.

A Padovani1, B Borroni, S M Brambati

  • 1Department of Medical Sciences, Neurology, University of Brescia, Italy. padovani@med.unibs.it

Journal of Neurology, Neurosurgery, and Psychiatry
|November 25, 2005
PubMed
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Progressive supranuclear palsy (PSP) involves early grey and white matter degeneration. This study used VBM and DTI to identify specific brain regions and white matter tracts affected in mild PSP.

Area of Science:

  • Neuroimaging
  • Neurology
  • Neurodegeneration

Background:

  • Progressive supranuclear palsy (PSP) is a common neurodegenerative disease.
  • A detailed characterization of grey and white matter changes in PSP is lacking.

Purpose of the Study:

  • To evaluate grey and white matter changes in mild PSP patients.
  • Utilize voxel-based morphometry (VBM) for grey matter analysis.
  • Employ diffusion tensor imaging (DTI) for white matter analysis.

Main Methods:

  • 14 mild PSP patients and 14 healthy controls participated.
  • Standardized clinical and neuropsychological evaluations were performed.
  • Structural MRI scans were analyzed using VBM and DTI to determine fractional anisotropy.

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Main Results:

  • VBM revealed reduced grey matter in PSP patients in the premotor cortex, frontal operculum, anterior insula, hippocampus, parahippocampal gyrus, thalamus, and superior/inferior colliculi.
  • DTI showed decreased fractional anisotropy in white matter tracts including the superior longitudinal fasciculus, corpus callosum, arcuate fasciculus, and internal capsule.
  • These changes were bilateral and suggest involvement of cortico-bulbar tracts.

Conclusions:

  • Early-stage PSP is characterized by both grey and white matter degeneration.
  • Atrophy in cortical and subcortical structures contributes to PSP.
  • Neurodegeneration of specific fiber tracts underlies the neurological deficits observed in PSP.