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[Antibiotic prophylaxis with aztreonam in general surgery].
F Martino1, M Bossotti, R Polastri
1II Divisione di Chirurgia Generale, Ospedale Gradenigo, Torino.
Minerva Medica
|June 1, 1992
Summary
Aztreonam (Azactam) is a useful parenteral antibiotic for surgical prophylaxis. In a study of 81 patients, it showed low infection rates, making it a recommended choice for abdominal surgery.
Area of Science:
- Infectious Diseases
- Surgical Infections
- Pharmacology
Context:
- Peroperative antibiotic prophylaxis is crucial in preventing surgical site infections.
- Abdominal surgery presents a significant risk for post-operative complications.
- Aztreonam is a synthetic broad-spectrum monobactam antibiotic.
Purpose:
- To evaluate the efficacy and safety of aztreonam (Azactam) as a prophylactic antibiotic in patients undergoing abdominal surgery.
- To assess the incidence of surgical wound and associated infections when using aztreonam.
- To determine the clinical utility, ease of administration, and side-effect profile of parenteral aztreonam.
Summary:
- A personal experience study involving 81 patients undergoing elective abdominal surgery reported the use of aztreonam (Azactam) for peroperative antibiotic prophylaxis.
- The study highlighted the drug's usefulness, ease of administration, and lack of reported side-effects.
- The incidence of surgical wound infections was 2.5%, and associated infections were 6.1%.
Impact:
- The findings support aztreonam as a valuable and effective option for peroperative antibiotic prophylaxis in abdominal surgery.
- The low incidence of infections suggests aztreonam can contribute to improved patient outcomes and reduced healthcare burden.
- Aztreonam is recommended as a drug of choice for peroperative prophylaxis based on these clinical results.