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[Antibiotic prophylaxis with aztreonam in general surgery]

F Martino1, M Bossotti, R Polastri

  • 1II Divisione di Chirurgia Generale, Ospedale Gradenigo, Torino.

Minerva Medica
|June 1, 1992
PubMed

Insights

Aztreonam (Azactam) is a useful parenteral antibiotic for surgical prophylaxis. In a study of 81 patients, it showed low infection rates, making it a recommended choice for abdominal surgery.

Area of Science:

  • Infectious Diseases
  • Surgical Infections
  • Pharmacology

Context:

  • Peroperative antibiotic prophylaxis is crucial in preventing surgical site infections.
  • Abdominal surgery presents a significant risk for post-operative complications.
  • Aztreonam is a synthetic broad-spectrum monobactam antibiotic.

Purpose:

  • To evaluate the efficacy and safety of aztreonam (Azactam) as a prophylactic antibiotic in patients undergoing abdominal surgery.
  • To assess the incidence of surgical wound and associated infections when using aztreonam.
  • To determine the clinical utility, ease of administration, and side-effect profile of parenteral aztreonam.

Summary:

  • A personal experience study involving 81 patients undergoing elective abdominal surgery reported the use of aztreonam (Azactam) for peroperative antibiotic prophylaxis.
  • The study highlighted the drug's usefulness, ease of administration, and lack of reported side-effects.
  • The incidence of surgical wound infections was 2.5%, and associated infections were 6.1%.

Impact:

  • The findings support aztreonam as a valuable and effective option for peroperative antibiotic prophylaxis in abdominal surgery.
  • The low incidence of infections suggests aztreonam can contribute to improved patient outcomes and reduced healthcare burden.
  • Aztreonam is recommended as a drug of choice for peroperative prophylaxis based on these clinical results.

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