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Alveolar soft-part sarcoma presenting with eosinophilia and shunt
M Almansori1, A R Turner, S Girgis
1Department of Medicine, University of Alberta, Edmonton.
Canadian Respiratory Journal
|November 25, 2005
Summary
Alveolar soft-part sarcoma (ASPS), a rare cancer, can present with unusual symptoms like eosinophilia and hypoxemia. This case highlights a unique association between ASPS and these findings, along with an arteriovenous shunt.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Alveolar soft-part sarcoma (ASPS) is a rare soft tissue neoplasm typically affecting young adults.
- ASPS commonly originates in skeletal muscle, particularly in the lower extremities.
Observation:
- A 34-year-old male presented with progressive dyspnea over 4-6 weeks.
- Clinical presentation included peripheral blood eosinophilia, hypoxemia, and a significant arteriovenous shunt.
Findings:
- Radiological and pathological confirmation of ASPS.
- This case represents the fourth reported instance of eosinophilia in sarcoma patients.
- Notably, this is the first documented association of eosinophilia with ASPS.
Implications:
- The findings suggest a potential paraneoplastic syndrome associated with ASPS.
- Highlights the importance of considering ASPS in young adults with unexplained respiratory symptoms and eosinophilia.
- Further research may elucidate the mechanisms linking ASPS and eosinophilia.