Related Experiment Video
Updated: Aug 14, 2026

GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
Published on: July 17, 2011
Potentiation of GABA-activated currents by imidazobenzoimidazole derivative RU-353 in isolated cerebellum Purkinje
N I Sharonova1, V S Vorob'ev, V G Skrebitskii
1Brain Research Institute, Russian Academy of Medical Sciences, Moscow.
Abstract:
Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 shifted the GABA dose-response curve to the left, but produced no effect on the maximum response (EC50 in control and in the presence of 30 microM RU-353 were 6.9 and 2.0 microM, respectively).
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
G-Protein Gated Ion Channels
Sensory organs,...

