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Antinociceptive effect from Ipomoea cairica extract.
A A Ferreira1, F A Amaral, I D G Duarte
1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
Journal of Ethnopharmacology
|November 26, 2005
Summary
Ipomoea cairica extract reduced pain and inflammation in mice, likely due to caffeoylquinic acids inhibiting histamine release. This plant extract shows potential for treating inflammatory conditions.
Area of Science:
- Pharmacology
- Ethnobotany
- Natural Products Chemistry
Background:
- Ipomoea cairica L. Sweet (Convolvulaceae) is utilized in Brazilian traditional medicine for managing rheumatism and inflammation.
- The plant's ethanolic extract has demonstrated anti-inflammatory properties in preliminary studies.
Purpose of the Study:
- To investigate the antinociceptive and anti-inflammatory effects of Ipomoea cairica ethanolic extract in preclinical models.
- To identify the active compounds responsible for the observed pharmacological effects.
Main Methods:
- Administration of Ipomoea cairica ethanolic extract to mice at varying doses (100–3000 mg/kg).
- Evaluation of antinociceptive effects using the formalin test and tail-flick reflex test.
- Assessment of anti-inflammatory activity via carrageenan-induced paw edema model.
- Motor coordination was assessed using the Rota-Rod test.
- Phytochemical analysis of the bioactive fraction to isolate active compounds.
Main Results:
- The extract exhibited a dose-dependent reduction in the inflammatory phase of the formalin test.
- No significant effects were observed on neurogenic pain, tail-flick reflex latency, carrageenan-induced paw edema, or motor performance.
- 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid were isolated from the bioactive fraction.
- These isolated compounds are known for their analgesic and antioxidative properties.
Conclusions:
- Ipomoea cairica ethanolic extract possesses antinociceptive properties, particularly against inflammatory pain.
- The isolated caffeoylquinic acid derivatives may contribute significantly to the extract's antinociceptive effects, potentially by inhibiting histamine release.
- Further research is warranted to fully elucidate the mechanisms of action and therapeutic potential of Ipomoea cairica.