Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antinociceptive effect from Ipomoea cairica extract.

A A Ferreira1, F A Amaral, I D G Duarte

  • 1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

Journal of Ethnopharmacology
|November 26, 2005
PubMed
Summary

Ipomoea cairica extract reduced pain and inflammation in mice, likely due to caffeoylquinic acids inhibiting histamine release. This plant extract shows potential for treating inflammatory conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of transversus abdominis plane and superficial serratus block for postoperative analgesia in dogs undergoing unilateral radical mastectomy.

Australian veterinary journal·2026
Same author

Pharmacological and toxicological effects of Amaryllidaceae.

Brazilian journal of biology = Revista brasleira de biologia·2023
Same author

A model for preservation of thymocyte-depleted thymus.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2023
Same author

Analgesia and pain: Dual effect of dopamine on the peripheral nociceptive system is dependent on D<sub>2</sub>-or D<sub>1</sub>-like receptor activation.

European journal of pharmacology·2022
Same author

Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2021
Same author

Co-codamol okay.

British dental journal·2020

Area of Science:

  • Pharmacology
  • Ethnobotany
  • Natural Products Chemistry

Background:

  • Ipomoea cairica L. Sweet (Convolvulaceae) is utilized in Brazilian traditional medicine for managing rheumatism and inflammation.
  • The plant's ethanolic extract has demonstrated anti-inflammatory properties in preliminary studies.

Purpose of the Study:

  • To investigate the antinociceptive and anti-inflammatory effects of Ipomoea cairica ethanolic extract in preclinical models.
  • To identify the active compounds responsible for the observed pharmacological effects.

Main Methods:

  • Administration of Ipomoea cairica ethanolic extract to mice at varying doses (100–3000 mg/kg).
  • Evaluation of antinociceptive effects using the formalin test and tail-flick reflex test.
  • Assessment of anti-inflammatory activity via carrageenan-induced paw edema model.

Related Experiment Videos

  • Motor coordination was assessed using the Rota-Rod test.
  • Phytochemical analysis of the bioactive fraction to isolate active compounds.

    • Main Results:

    • The extract exhibited a dose-dependent reduction in the inflammatory phase of the formalin test.
    • No significant effects were observed on neurogenic pain, tail-flick reflex latency, carrageenan-induced paw edema, or motor performance.
    • 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid were isolated from the bioactive fraction.
    • These isolated compounds are known for their analgesic and antioxidative properties.

    Conclusions:

    • Ipomoea cairica ethanolic extract possesses antinociceptive properties, particularly against inflammatory pain.
    • The isolated caffeoylquinic acid derivatives may contribute significantly to the extract's antinociceptive effects, potentially by inhibiting histamine release.
    • Further research is warranted to fully elucidate the mechanisms of action and therapeutic potential of Ipomoea cairica.