Chemical constituents from Schisandra plena

Area of Science:

• Natural Product Chemistry
• Phytochemistry
• Organic Chemistry

Background:

• Schisandra plena is a plant species with potential for novel chemical discoveries.
• Previous phytochemical investigations of Schisandra species have revealed diverse bioactive compounds.
• Understanding the chemical profile of S. plena is crucial for its potential applications.

Purpose of the Study:

• To conduct the first-time chemical investigation of the leaves and stems of Schisandra plena.
• To isolate and characterize new and known chemical constituents from S. plena.
• To determine the structure and stereochemistry of isolated compounds using spectroscopic methods.

Main Methods:

• Extraction and isolation of chemical constituents from S. plena using chromatographic techniques.
• Structure elucidation of isolated compounds, including a new sesquiterpenoid, plenoxide (1), via comprehensive spectroscopic analysis (1D and 2D NMR, MS).
• Comparison of spectroscopic data with known compounds, leading to revision of existing data for similar structures.

Main Results:

• Isolation and identification of a novel sesquiterpenoid, named plenoxide (1).
• Identification of eleven known compounds: sesquiterpenoids, coumarins, flavanones, triterpenoids, and steroids.
• Determination of the structure and stereochemistry of plenoxide (1) through detailed spectroscopic analysis.
• Revision of chemical shift assignments for compounds structurally related to bullatantriol based on 2D NMR data analysis.

Conclusions:

• The chemical constituents of Schisandra plena have been described for the first time, revealing a novel sesquiterpenoid, plenoxide.
• This study expands the known chemical diversity within the Schisandra genus.
• The revision of spectroscopic data for bullatantriol-like compounds highlights the importance of re-evaluating existing natural product data.