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Central nervous system malignant lymphoma associated with Behcet's disease. Case report
Yasuki Ono1, Masatoshi Yamada, Tsuyoshi Kawamura
1Department of Neurosurgery, Hachinohe City Hospital. cjl90720@ams.odn.ne.jp
Neurologia Medico-Chirurgica
|November 26, 2005
Summary
This study reports a rare case of intracranial B-cell lymphoma in a patient with Behcet's disease. The rare association highlights the need for vigilance in diagnosing neurological complications in Behcet's patients.
Area of Science:
- Neuro-oncology
- Rheumatology
- Immunology
Background:
- Behcet's disease is a rare multisystem inflammatory disorder.
- Intracranial involvement in Behcet's disease is uncommon, typically presenting as vasculitis.
- Malignant lymphoma is an exceptionally rare complication of Behcet's disease.
Observation:
- A 75-year-old woman with a 17-year history of incomplete Behcet's disease presented with headache and dizziness.
- Computed tomography revealed a large enhancing mass with surrounding edema in the right frontal lobe.
- Surgical resection yielded a discolored red mass and hematoma.
Findings:
- Histological examination confirmed the mass as a B-cell type malignant lymphoma.
- This represents one of the few reported cases of lymphoma co-occurring with Behcet's disease.
- The patient had a prolonged treatment history with prednisolone and colchicine.
Implications:
- This case underscores the importance of considering rare neurological complications, including malignancy, in patients with Behcet's disease.
- Further research is needed to understand the potential link between chronic inflammation, immunosuppression, and lymphomagenesis in Behcet's disease.
- This finding may prompt closer oncological surveillance in long-standing Behcet's disease cohorts.