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Prosthetic vascular graft infection: a risk factor analysis using a case-control study.
Vera S Antonios1, Audra A Noel, James M Steckelberg
1Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA. vantonios1@hotmail.com
The Journal of Infection
|November 29, 2005
Summary
Groin incisions, wound complications, and wound infections significantly increase the risk of prosthetic vascular graft infection (PVGI). Identifying these factors helps manage patients at higher risk for PVGI.
Area of Science:
- Vascular Surgery
- Infectious Diseases
- Biostatistics
Background:
- Prosthetic vascular graft infection (PVGI) is a severe complication with high mortality and amputation rates.
- Several factors are anecdotally linked to PVGI, but require statistical validation.
Purpose of the Study:
- To statistically confirm purported risk factors for prosthetic vascular graft infection (PVGI).
- To identify key predictors for PVGI in patients undergoing vascular graft placement.
Main Methods:
- A retrospective case-control study was conducted at Mayo Clinic, Rochester, MN.
- Fifty-one PVGI cases were matched with 102 controls based on age, gender, and surgery date.
- Statistical analyses, including univariate and multivariate models, were employed to assess risk factors.
Main Results:
- Groin incision, wound complication, and wound infection were identified as significant risk factors for PVGI through univariate analysis (p<0.005).
- Multivariate analysis confirmed groin incision and wound infection as statistically significant predictors of PVGI, after adjusting for age and surgery date.
- Staphylococcal species were the most common organisms identified in cases with recovered organisms (60%).
Conclusions:
- Groin incision, wound complication, and wound infection are significantly associated with the development of PVGI.
- This study provides the first published statistical risk factor analysis for PVGI using a case-control design.
- Findings aid in identifying patients at increased risk for PVGI, facilitating targeted prevention and management strategies.