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Hypertriglyceridemia and hypercholesterolemia in human immunodeficiency virus-1-infected children treated with

Fortino Solórzano Santos1, Laura G Gochicoa Rangel, Gerardo Palacios Saucedo

  • 1Infectious Diseases Department, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F., México. forsosa@starmedia.com

Archives of Medical Research
|November 30, 2005
PubMed

Insights

Highly active antiretroviral therapy (HAART) in children with HIV-1 can lead to frequent hyperlipidemia, characterized by high cholesterol and triglyceride levels. Further research is needed to explore management strategies for dyslipidemia in this population.

Area of Science:

  • Pediatric Infectious Diseases
  • Cardiovascular Health in HIV
  • Pharmacological Adverse Effects

Background:

  • Highly active antiretroviral therapy (HAART) is associated with adverse effects, including dyslipidemia, in both adult and pediatric patients.
  • Protease inhibitors (PIs) are a key component of HAART regimens implicated in these metabolic changes.

Purpose of the Study:

  • To monitor cholesterol and triglyceride levels in a cohort of HIV-1-infected children receiving HAART.
  • To assess the incidence of hyperlipidemia in pediatric patients undergoing antiretroviral treatment.

Main Methods:

  • Enrolled HIV-infected patients under 17 years old in a longitudinal cohort study.
  • Measured fasting serum cholesterol and triglyceride levels every 3 months.
  • Patients received HAART regimens including nucleoside reverse transcriptase inhibitors and protease inhibitors.

Main Results:

  • Hypercholesterolemia (62.5%) and hypertriglyceridemia (79.2%) were frequent findings in the pediatric cohort.
  • Lipid abnormalities typically emerged after 15 months of antiretroviral treatment.
  • No cases of lipodystrophy were observed in the study participants.

Conclusions:

  • Hyperlipidemia is a common complication in HIV-1-infected children treated with PI-containing antiretroviral regimens.
  • Larger studies with extended follow-up are necessary to determine optimal management and alternative treatments for dyslipidemia in this population.
Abstract

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