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[Multiple hepatocellular carcinomas successfully treated by combined therapies]
Toshiya Ochiai1, Teruhisa Sonoyama, Shojiro Kikuchi
1Dept. of Surgery, Kyoto Prefectural University of Medicine.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|December 1, 2005
Summary
This case study shows successful treatment of advanced hepatocellular carcinoma (HCC) using a combination of transarterial chemoembolization (TAE), surgery, and radiofrequency ablation (RFA). This multimodal approach achieved long-term remission in a challenging HCC case.
Area of Science:
- Hepatobiliary Surgery
- Interventional Radiology
- Medical Oncology
Background:
- Hepatocellular carcinoma (HCC) presents a significant global health challenge, often diagnosed at advanced stages.
- Multifocal HCC requires complex treatment strategies for optimal patient outcomes.
- Combination therapies are increasingly explored for managing advanced liver cancer.
Observation:
- A 59-year-old male presented with advanced, multifocal hepatocellular carcinoma (HCC).
- Initial treatment involved transarterial chemoembolization (TAE) and percutaneous ethanol injection therapy (PEIT).
- Despite initial response, frequent recurrences necessitated repeated TAE (12 times) followed by right trisegmentectomy.
Findings:
- Post-surgery, a new HCC lesion in subsegment 3 was successfully treated with radiofrequency ablation (RFA).
- A solitary lung metastasis was surgically resected.
- The patient remained disease-free for 82 months post-initial HCC detection, demonstrating sustained remission.
Implications:
- This case highlights the efficacy of a multimodal treatment strategy combining TAE, surgery, and RFA for advanced HCC.
- Aggressive and tailored therapeutic interventions can achieve long-term disease control in complex HCC cases.
- Successful management of multifocal HCC and distant metastasis is achievable with a combination approach.