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[Gastroretentive dosage forms]
1Semmelweis Egyetem Budapest, Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet, Budapest, Hogyes Endre u. 7-9. - 1092.
Acta Pharmaceutica Hungarica
|December 2, 2005
Summary
Gastroretentive dosage forms prolong drug release in the stomach for enhanced absorption or local therapy. Further research is needed to predict in vivo behavior and clinical application of these advanced drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Gastrointestinal Physiology
Context:
- Gastroretentive dosage forms (GRDFs) are designed to retain drugs in the stomach for extended periods.
- This extended gastric residence time allows for controlled drug release, improving therapeutic outcomes for specific drugs.
- GRDFs are particularly beneficial for drugs absorbed in the upper GI tract or those unstable in distal regions, and for local stomach therapy.
Purpose:
- To review the principles, design strategies, and challenges associated with gastroretentive dosage forms.
- To highlight the advantages of GRDFs for specific drug properties and therapeutic needs.
- To identify areas requiring further development for successful clinical implementation.
Summary:
- Gastroretentive dosage forms prolong gastric residence time through various mechanisms like floating, expanding, bioadhesion, modified shape, or high density.
- These systems offer spatial and temporal control over drug liberation, crucial for drugs absorbed in the upper GI tract or requiring local stomach treatment.
- Despite innovative designs, challenges remain in predicting in vivo performance and ensuring seamless integration into clinical practice.
Impact:
- Advances in gastroretentive drug delivery can significantly improve the efficacy and safety of medications.
- Successful implementation of GRDFs could lead to more targeted and effective treatments for gastrointestinal disorders.
- Further research into predicting in vivo behavior will bridge the gap between formulation development and clinical application, enhancing patient care.