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[How much vitamin B6 is toxic?].

¹Wageningen Centre for Food Sciences en Wageningen Universiteit, afd. Humane Voeding, Bomenweg 2, 6703 HD Wageningen. martijn.katan@wur.nl

Nederlands Tijdschrift Voor Geneeskunde

|December 3, 2005

Summary

High vitamin B6 intake, especially above 1000 mg daily, can cause neuropathy. Physicians should monitor patients for nerve damage linked to excessive pyridoxine supplementation.

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Area of Science:

Neuroscience
Nutritional Science
Toxicology

Context:

Vitamin B6 (pyridoxine) is essential but can be toxic at high doses.
Established safe upper intake levels exist, yet toxicity reports vary.
Understanding dose-dependent neurotoxicity is crucial for public health.

Purpose:

To review the established and potential neurotoxic effects of vitamin B6.
To inform healthcare professionals about the risks associated with high pyridoxine intake.

Summary:

Vitamin B6 (pyridoxine) intake of 1000 mg/day or more is linked to neuropathy.
Occasional toxicity reports exist at 100-300 mg/day; US safe upper limit is 100 mg/day.
Low-dose neurotoxicity reports (24-40 mg/day) may be coincidental; vigilance for high intakes is advised.

Impact:

Highlights the importance of adhering to recommended vitamin B6 intake levels.
Emphasizes physician awareness of potential pyridoxine-induced neuropathy in unexplained cases.
Contributes to informed public health guidelines regarding vitamin B6 supplementation.

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