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Effects of topical sesame oil on oxidative stress in rats
James Po-Jung Chiang1, Dur-Zong Hsu, Jui-Chen Tsai
1Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan.
Objective:
To assess the effects of topical sesame oil on systemic oxidative stress in rats.
Design:
Oxidative stress was induced with lipopolysaccharide and assessed by determining serum lipid peroxidation, superoxide anion, and hydroxyl radical levels. The levels of 3 circulating antioxidants--superoxide dismutase, catalase, and glutathione--also were determined.
Results:
Topical sesame oil significantly reduced lipid peroxidation, superoxide anion, and hydroxyl radical levels after lipopolysaccharide administration. However, sesame oil did not affect the 3 circulating antioxidants. Further, sesame oil decreased the activity of xanthine oxidase and nitric oxide production in lipopolysaccharide-treated rats.
Conclusion:
Sesame oil given topically might attenuate oxidative stress by inhibiting the production of xanthine oxidase and nitric oxide in rats.