Prognostic factors in oral cavity carcinomas

Area of Science:

• Oncology
• Pathology

Background:

• Oral cavity carcinoma is a significant health concern.
• A substantial proportion of patients present with advanced disease stages.

Purpose of the Study:

• To investigate the clinical characteristics and prognostic factors of oral cavity carcinoma.
• To identify parameters influencing patient survival.

Main Methods:

• Retrospective analysis of 176 patients with oral cavity carcinoma.
• Statistical analysis including Cox regression to determine survival influences.

Main Results:

• Approximately 60% of patients presented with advanced stage disease.
• Shorter symptom duration correlated with larger tumors and presence of metastases.
• Lymph node metastases were associated with larger tumors, high malignancy grade, and non-diploid tumors.
• Tumor size, lymph node metastases, and DNA ploidy were significant predictors of survival.

Conclusions:

• Advanced stage at presentation is common in oral cavity carcinoma.
• Tumor size, lymph node metastasis, and DNA ploidy are critical prognostic indicators for survival.