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Related Experiment Videos

Pulsatile pediatric ventricular assist devices.

William J Weiss1

  • 1Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 3, 2005
PubMed
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A new pulsatile pediatric ventricular assist device (PVAD) is being developed for infants and children, offering physiologic pulsatility for mechanical circulatory support. This device aims to improve outcomes for pediatric patients requiring temporary heart assistance.

Area of Science:

  • Biomedical Engineering
  • Pediatric Cardiology
  • Medical Devices

Background:

  • Mechanical circulatory support is crucial for infants and children with heart failure.
  • Existing devices are often adapted from adult designs, posing challenges for pediatric application.
  • The development of a dedicated pediatric ventricular assist device (PVAD) is needed.

Purpose of the Study:

  • To develop and characterize a pulsatile pediatric ventricular assist device (PVAD) for mechanical circulatory support in pediatric patients.
  • To adapt the established Pierce-Donachy VAD design for infant and child-specific needs.
  • To evaluate the device's performance and suitability for various clinical scenarios.

Main Methods:

  • Design adaptation of the adult Pierce-Donachy VAD for pediatric use.

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  • Development of infant (13 ml) and planned child (25 ml) sizes.
  • Utilizing pneumatic actuation with a full-to-empty control mode for flexible biventricular assistance.
  • In vitro testing including hydrodynamic performance, hemolysis, and flow velocity measurements via particle image velocimetry.
  • Planning for in vivo implantation studies in juvenile animals.

    • Main Results:

    • The PVAD is designed with stroke volumes (13 ml and 25 ml), beat rates, and pulsatility comparable to normal physiologic values.
    • The device allows for flexible application in left, right, or biventricular assistance.
    • In vitro testing is in progress to assess key performance metrics.

    Conclusions:

    • The developed PVAD shows promise for providing effective mechanical circulatory support in pediatric populations.
    • The device's design offers physiologic pulsatility and flexibility for diverse clinical needs.
    • Further in vitro and in vivo studies are essential to validate its safety and efficacy.