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Related Experiment Videos

Blood plasma separation in microfluidic channels using flow rate control.

Sung Yang1, Akif Undar, Jeffrey D Zahn

  • 1Department of Bioengineering, Pennsylvania State University, University Park, PA, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 3, 2005
PubMed
Summary

A new microfluidic device enables continuous, real-time plasma separation from blood. This innovation aids in studying inflammatory responses during cardiac surgery and developing new treatments.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Inflammation Research

Background:

  • Cardiac surgery, especially with cardiopulmonary bypass (CPB), triggers systemic inflammatory responses.
  • Postoperative complications are often linked to this inflammation, but effective prevention is lacking.
  • Timely measurement of inflammatory markers is crucial for clinical intervention and research, yet current methods are limited.

Purpose of the Study:

  • To introduce a novel microfluidic device for continuous, real-time blood plasma separation.
  • To enable integration with downstream analytical devices for immediate plasma analysis.
  • To address the need for timely inflammatory response measurements in patients undergoing CPB.

Main Methods:

  • Design and simulation of a microfluidic device with whole blood inlet, plasma outlet, and concentrated blood cell outlet.

Related Experiment Videos

  • Computational fluid dynamics (CFD) simulations to predict plasma separation efficiency at varying hematocrit levels.
  • Experimental validation using defibrinated sheep blood to demonstrate device functionality and cell viability.

    • Main Results:

    • The microfluidic device successfully separated plasma from whole blood with high hematocrit (up to 45%).
    • CFD simulations predicted efficient plasma collection (27% at 45% hematocrit, 25% at 39% hematocrit).
    • Experimental results confirmed continuous plasma separation without cell clogging or lysis, demonstrating device feasibility.

    Conclusions:

    • The developed microfluidic device offers a simple, efficient solution for real-time, cell-free plasma separation.
    • This technology can facilitate continuous monitoring of inflammatory markers during and after cardiac surgery.
    • The device holds potential for improving clinical management and research into CPB-induced inflammatory responses.