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[Isolated pathogen microorganisms in respiratory samples from children with cystic fibrosis]

M M Anzaudo1, N P Busquets, S Ronchi

  • 1Sección Bacteriología del Hospital de Niños Dr. Orlando Alassia Mendoza 4151, 3000, Santa Fe, Argentina. milanzaudo@yahoo.com.ar

Revista Argentina De Microbiologia
|December 6, 2005
PubMed

Insights

Cystic Fibrosis patients frequently harbor Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus spp. in their respiratory tracts. High antibiotic resistance rates were observed in these common CF pathogens, posing treatment challenges.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Cystic Fibrosis (CF) involves exocrine gland dysfunction, frequently leading to respiratory complications.
  • Chronic respiratory tract colonization by bacteria like Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus spp. is a major cause of morbidity and mortality in CF patients.

Purpose of the Study:

  • To analyze the prevalence and antibiotic resistance patterns of key bacterial pathogens in respiratory samples from pediatric Cystic Fibrosis patients.

Main Methods:

  • Respiratory samples were collected from pediatric CF patients (4 months to 11 years) between November 2001 and August 2004.
  • Microbiological analysis identified the most frequent bacterial isolates.
  • Antibiotic susceptibility testing was performed on isolated strains.

Main Results:

  • Staphylococcus aureus (38.7%), Pseudomonas aeruginosa (37.4%), and Haemophilus spp. (15.3%) were the most common isolates.
  • High resistance rates were found in S. aureus (erythromycin 35.0%, clindamycin 29.4%, methicillin-resistant 25.9%).
  • P. aeruginosa showed significant gentamicin resistance (31.0%), while Haemophilus spp. exhibited ampicillin (23.0%) and trimethoprim-sulfamethoxazole (59.0%) resistance.

Conclusions:

  • Pediatric CF patients are frequently colonized by S. aureus, P. aeruginosa, and Haemophilus spp.
  • Significant antibiotic resistance, including MRSA and resistance to common treatments, is prevalent in these pathogens.
  • These findings highlight the urgent need for effective antimicrobial strategies in CF respiratory care.

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