Related Experiment Video
Updated: Aug 14, 2026

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
Published on: November 11, 2022
Adrenergic-mediated exposure of hyperkalemia in the electrocardiogram
Abstract:
We document full exposure of the electrocardiographic hyperkalemia signs brought about by exogenous epinephrine in a patient on long-term beta-blockade treatment in whom spironolactone-induced hyperkalemia developed. We propose that the stimulated adrenergic receptor promoted re-expression of two main potassium channels (I(Kr), I(Ks)) involved in ventricular repolarization, modifying the ECG waveform. The effects of hyperkalemia could be aggravated in the presence of beta-adrenergic blockade.
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