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New megastigmane glucosides from Excoecaria cochinchinensis LOUR. var. cochinchinensis

Phan Minh Giang1, Phan Tong Son, Katsuyoshi Matsunami

  • 1Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi.

Chemical & Pharmaceutical Bulletin
|December 6, 2005
PubMed

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Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...