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Updated: Feb 17, 2026

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
Published on: August 13, 2020
[Corticotropic axis and chronic stress in abdominal obesity and metabolic syndrome]
S Boullu-Ciocca1, P Verger, A Bocquier
1Service d'endocrinologie, des maladies métaboliques et de la nutrition, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille, Marseille (13).
Abstract:
Several indicators of corticotropic axis hyperactivity have been observed in common abdominal obesity, which is clinically similar to the obesity found in Cushing's syndrome. Corticotropic axis hyperactivity may be involved in the development and metabolic and cardiovascular complications of abdominal obesity. Several mechanisms may be responsible for this hormonal dysregulation: genetic, lifestyle, and nutritional factors, and chronic stress. We note the necessity of methodologically-impeccable clinical studies for an objective evaluation of the role of stress in obesity.
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