Mechanisms of rhythmogenesis: insights from hypothalamic vasopressin neurons

Many neurons in the CNS, including hypothalamic vasopressin-expressing cells, display rhythmic activity patterning. These vasopressin neurons receive random synaptic input but fire action potentials in alternating periods of activity and silence that each lasts tens of seconds. Recent work demonstrates that vasopressin cell rhythmicity depends on feedback modulation of intrinsic membrane properties and synaptic inputs by peptides released from the dendrites of these neurons. Many other neurons across the CNS release neurotransmitters from their dendrites; therefore, vasopressin cells provide an insight into the potential mechanisms that support neuronal activity patterning across the CNS.