Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulating GABA modulators.

Carol A Paronis1

  • 1McLean Hospital, Harvard Medical School, Belmont, MA, USA. cparonis@hms.harvard.edu

British Journal of Pharmacology
|December 7, 2005
PubMed
Summary

New research shows that combining GABA modulators can have complex effects. Low-efficacy benzodiazepines can block some effects while enhancing others, challenging previous assumptions about independent receptor sites.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contextual Influences on Naltrexone Sensitization During Daily Morphine Exposure.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Xanomeline treatment attenuates cocaine self-administration in rats and nonhuman primates.

Neuropharmacology·2025
Same author

Effects of inhaled low-concentration xenon gas on naltrexone-precipitated withdrawal symptoms in morphine-dependent mice.

Drug and alcohol dependence·2023
Same author

The Effects of Chronic Naltrexone on Reinstatement of Opioid-Induced Drug-Seeking Behavior and Antinociception.

The Journal of pharmacology and experimental therapeutics·2023
Same author

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans.

Molecules (Basel, Switzerland)·2023
Same author

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.

Molecules (Basel, Switzerland)·2022

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • GABAergic neurotransmission is modulated by various compounds acting at distinct GABAA receptor sites.
  • Previous research on combined GABA modulator effects yielded limited or additive results, suggesting independent site interactions.

Discussion:

  • This study investigates the interaction between benzodiazepine and neurosteroid binding sites on GABAA receptors.
  • McMahon and France demonstrate that low-efficacy benzodiazepine ligands can antagonize midazolam and enhance neurosteroid effects simultaneously.

Key Insights:

  • Contrary to prior beliefs, GABAA receptor sites do not always modulate GABA effects independently.
  • Low-efficacy benzodiazepines exhibit complex modulatory actions, affecting different ligands differently.

Outlook:

  • These findings necessitate a re-evaluation of GABAA receptor pharmacology and drug development strategies.
  • Further research is needed to elucidate the mechanisms underlying the interaction between different allosteric sites on GABAA receptors.

Related Experiment Videos