Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mouse models of ocular diseases.

B Chang1, N L Hawes, R E Hurd

  • 1The Jackson Laboratory, Bar Harbor, ME 04609-1500, USA. bchang@jax.org

Visual Neuroscience
|December 8, 2005
PubMed
Summary

Researchers identified 109 new mouse models for eye disorders, aiding the study of genetic conditions like glaucoma and cataracts. These mouse models offer valuable insights into human eye diseases, facilitating genetic analysis and gene identification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical implementation challenges of component-resolved diagnostics in allergy and countermeasures through continuing medical education].

Zhonghua yi xue za zhi·2026
Same author

[Multicenter component-resolved study of inhalant allergen sensitization and cross-reactivity in airway allergic patients].

Zhonghua yi xue za zhi·2026
Same author

[Primary SMARCA4-deficient triple-negative breast cancer: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same author

[Precise diagnosis of allergic diseases: construction of a clinical decision-making system based on epidemiology and quantitative IgE testing].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

Optimizing the impact of supportive cancer care digital health interventions: considerations for design, development, and evaluation.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2025
Same author

[Application analysis of clinical implementation and educational promotion of allergen testing in the standardization of diagnosis and treatment].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025

Area of Science:

  • Genetics
  • Ophthalmology
  • Animal Models

Background:

  • The Jackson Laboratory maintains extensive mouse collections, crucial for identifying genetic models of human diseases.
  • Research into human eye disorders is often limited by ethical and practical constraints in studying human subjects.
  • Genetic mouse models are essential for understanding the pathophysiology and genetic basis of inherited ocular conditions.

Purpose of the Study:

  • To catalog and describe available mouse models for ocular research at The Jackson Laboratory.
  • To identify and characterize novel spontaneous mouse mutants with genetic eye variations and disorders.
  • To highlight the utility of mouse models in studying human eye diseases.

Main Methods:

  • Screening of mouse strains and stocks at The Jackson Laboratory.

Related Experiment Videos

  • Characterization using indirect ophthalmoscopy, fundus photography, electroretinography (ERG), and histology.
  • Genetic analysis including linkage studies and gene identification.

    • Main Results:

    • Discovery of 109 new spontaneous mouse mutants affecting various eye structures (lid, cornea, iris, lens, retina).
    • Identified disorders include corneal diseases, glaucoma, cataracts, and retinal degenerations.
    • Established relevance of mouse findings to homologous human ocular conditions.

    Conclusions:

    • Mouse models are invaluable tools for the genetic analysis and gene identification of ocular diseases.
    • The identified mouse mutants provide critical resources for understanding the mechanisms of human eye conditions.
    • Continued research using these models promises advancements in diagnosing and treating human eye diseases.