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Updated: Aug 14, 2026

Mapping Infant Immunity with Minimal Input: Integrative Single-Cell and Multiomic Profiling
Published on: April 3, 2026
[Febrile infant and small child: what solution could be rational?]
1Clinic of Children's Diseases, Kaunas University of Medicine, 50009 Kaunas, Lithuania. rimantas_kevalas@hotmail.com
Insights
Fever in young children can stem from serious bacterial infections. This review validates optimal management strategies to safely screen febrile infants and children for these infections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Emergency Medicine
Background:
- Fever in infants and young children is a common parental concern, often caused by viral infections but potentially indicating serious bacterial infections.
- Infants and children up to 36 months are at the highest risk for invasive bacterial infections, which can lead to severe disability or death if unidentified.
Purpose of the Study:
- To review existing data and validate optimal recommendations for the evaluation and management of febrile infants and children aged 3 to 36 months.
- To address the critical question of when a febrile infant can be safely discharged from the emergency room.
Main Methods:
- Review of prospective studies and established recommendations for febrile infant management.
- Analysis of criteria used in screening for serious bacterial infections, including age, temperature, clinical appearance, and laboratory/radiological findings.
Main Results:
- Established criteria from major studies provide a safe and effective method for screening febrile infants for serious bacterial infections.
- Management strategies incorporate various clinical and diagnostic parameters to guide decision-making.
Conclusions:
- Physicians need clear evaluation and management tactics to prevent missed serious bacterial infections in febrile infants.
- Validated criteria are essential for safely discharging febrile infants and children from emergency care.
Abstract:
Fever of infant and small child is one of the greatest parental concerns. Mostly the source of fever is viral infection, but sometimes it can be serious bacterial infection: meningitis, sepsis, osteomyelitis, urinary tract infection, pneumonia and enteritis. Non-identified bacterial infection may be a cause of disablement or even death. Infant and younger children up to 36 months of age are in the highest risk period for invasive bacterial infection. After the examination of febrile infant the practitioner has to take a wise decision, especially if febrile infant looks well enough and there is no focus of infection. It is not reasonable to admit all febrile infants and do tests to all of them or start empiric antibiotic therapy. In order to protect infants from no identification of serious bacterial infection it is important for a physician to know the evaluation and management tactics of febrile infants. Thus, the salient question for any physician is: "When can a febrile infant be safely discharged from the emergency room?" Most often proposed recommendations for the management of febrile infants in the literature come predominantly from Boston, Philadelphia and Rochester prospective studies. Criteria introduced in these recommendations demonstrate a safe and effective way of screening febrile infants for a serious bacterial infection. Each management strategy involves criteria such as child's age, temperature, clinical appearance, white blood cell count, urinalysis, cerebrospinal fluid test, stool screening, chest radiography. The purpose of this article is to review the data and to validate optimal recommendation regarding the management of febrile infant and child 3 to 36 months of age.
