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Updated: Aug 14, 2026
Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples
Published on: August 7, 2016
Rapid separation of strychnine and brucine on a dynamically modified poly(dimethylsiloxane) microchip followed by
1Key Lab of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, 210093, Nanjing, PR China.
Abstract:
A method has been developed for rapidly separating and detecting strychnine and brucine using a poly(dimethysiloxane) (PDMS) microchip and electrochemical (EC) detection. PDMS microchannels dynamically modified by Brij35 are shown to be more efficient than native ones. The two analytes are well separated within 90 s in 70 mmol/L acetate buffer (pH 5.5) containing 0.01% (v/v) Brij35. Detection limits were found to be 1.0 micromol/L for strychnine and 0.2 micromol/L for brucine at S/N = 3. The method was used to determine trace strychnine and brucine in rat serum, and the results obtained correlate well with those obtained via high-performance liquid chromatography (HPLC).
