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Updated: Aug 14, 2026
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
Favorable histology, MYCN-amplified 4S neonatal neuroblastoma
Edward L Chan1, Richard E Harris, Kathleen H Emery
1Division of Pediatric Hematology/Oncology, State University of New York at Stony Brook, Stony Brook, New York 11776, USA. elchan@notes.cc.sunysb.edu
Abstract:
We report a neonate with 4S neuroblastoma and MYCN amplification, but favorable Shimada histology, successfully treated with chemotherapy and 13-cis-retinoic acid without stem cell transplantation. MYCN amplification in neuroblastoma is usually associated with unfavorable Shimada histology; the presence of these features in infants with 4S disease confers a poor prognosis. A small number of infants with 4S neuroblastoma and MYCN amplification have favorable Shimada histology. In this subgroup of infants, histopathology may be equally important in predicting outcome.
