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Updated: Aug 14, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
[Leucemogenesis of chronic myelogenous leukemia]
1Laboratoire d'hématologie, CHU de Bordeaux, Inserm E0217, Université Victor Segalen-Bordeaux 2, 33076 Bordeaux Cedex. francois-xavier.mahon@umr5540.u-bordeaux2.fr
Abstract:
Chronic myelogenous leukemia is a model for the explaining between dysregulation of tyrosine-kinase and cellular transformation. BCR-ABL protein providing from the abnormal gene is the biological marker of the leukemic cells. It is the molecular counterpart of the chromosomal abnormality that is also called Philadelphia chromosome. Since BCR-ABL drives the leukemic proliferation, it became recently a specific target to develop the tyrosine-kinase inhibitors. These new specific drugs and their effects on the chronic myelogenous leukemia must be taken into account to explain the physiopathology of the disease.
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