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Effect of cog threads under rat skin.
Hyo Jook Jang1, Won Seok Lee, Kun Hwang
1Department of Plastic Surgery, Inha University, Incheon, Korea.
Summary
Cog threads offer superior tensile strength for skin tightening compared to other types. Myofibroblasts contribute to tissue contracture, supporting clinical applications for aging facial skin.
Area of Science:
- Biomaterials Science
- Dermatology
- Regenerative Medicine
Background:
- Aging leads to loss of facial skin tensile strength.
- Cog threads are a recent innovation for tightening lax skin and soft tissues.
Purpose of the Study:
- To comparatively analyze the effects of cog, monofilament, and multifilament threads.
- To evaluate thread strength and tissue response under the skin.
Main Methods:
- Insertion of cog, monofilament, and multifilament threads into cadaver and rat skin.
- Measurement of maximum holding strength (MHS) and skin tearing strength.
- Histological analysis of capsule thickness and myofibroblast presence.
Main Results:
- Cog threads exhibited significantly higher MHS in both cadaver and rat models compared to monofilament and multifilament threads.
- Histological examination revealed a thicker capsule and a greater number of myofibroblasts around cog threads.
- Skin laxity temporarily resolved but returned to baseline within two weeks for all thread types.
Conclusions:
- Cog threads provide immediate lifting and tightening of skin and subcutaneous tissue.
- Myofibroblasts play a crucial role in fibrous tissue contracture around threads, observed four weeks post-insertion.
- The study's findings support the potential clinical efficacy of cog threads for aesthetic facial rejuvenation.