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Updated: Aug 14, 2026

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
A comparison of two botulinum type a toxin preparations for the treatment of glabellar lines: double-blind,
Philippa L Lowe1, Rickie Patnaik, Nicholas J Lowe
1Cranley Clinic, London, UK.
Background:
Botulinum toxins have been proven effective for reducing facial lines. There are two commercial types of botulinum toxin type A available in many countries but no published comparison studies.
Objective:
To compare the efficacy and tolerability of Botox Cosmetic and Dysport 50 U in the treatment of glabellar lines (using 20 U of Botox Cosmetic, which is the dose approved by the US Food and Drug Administration for the treatment of glabellar lines, and 50 U of Dysport, which has been reported to be the optimal dose for this formulation).
Study Design:
Parallel-group double-blind pilot study. Evaluation by observing physician, photographic, and patient evaluations.
Conclusion:
Botox 20 U provided better and more prolonged efficacy than Dysport 50 U in the treatment of glabellar lines.
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