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Updated: Mar 19, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Photodynamic Therapy: A Clinical Consensus Guide
David M Ozog1, Ali M Rkein, Sabrina G Fabi
1*Department of Dermatology, Henry Ford Hospital, Detroit, Michigan; †English Dermatology, Gilbert, Arizona; ‡Cosmetic Laser Dermatology, San Diego, California; §University of California, San Diego, California; ¶Gold Skin Care Center, Nashville, Tennessee; ‖Cosmetic Laser Dermatology, San Diego, California; #Department of Dermatology, University of California, San Diego, California; **Cranley Clinic, London, United Kingdom; ††Dermatology Associates, Maui, Hawaii; ‡‡Dermatology, Laser, and Vein Specialists of the Carolinas, Charlotte, North Carolina; §§Wake Forest School of Medicine, Winston Salem, North Carolina.
Background:
The American Society of Dermatologic Surgery (ASDS) periodically develops consensus documents for its members concerning various aspects of dermatologic surgery. Advances in photodynamic therapy (PDT) have been many and PDT use has been established in a variety of skin conditions.
Objective:
The ASDS board of directors proposed a committee of experts in the field to develop consensus documents on different treatments. An expert panel reviewed the literature on PDT and discussed the findings. The consensus was reached with evidence-based recommendations on different clinical applications for PDT.
Patients And Methods:
This consensus document includes discussions regarding PDT, including different photosensitizers and various light source activators, historical perspective, mechanism of action, various therapeutic indications and expected outcomes, pre- and post-care, and management of adverse outcomes.
Results:
Photodynamic therapy is highly effective for pre-cancerous lesions, superficial nonmelanoma skin cancers, inflammatory acne vulgaris and other conditions. New protocols including laser mediated PDT significantly improve results for several indications.
Conclusion:
The ASDS consensus document on PDT will be helpful for educating members on safe and effective PDT for a variety of indications.
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