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Electrophysiologic findings in optic nerve dysfunction associated with multiple evanescent white-dot syndrome
N Takeda1, K Numata, S Yamamoto
1Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Japan.
Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1992
Summary
This study details electrophysiologic findings in a patient with multiple evanescent white-dot syndrome (MEWDS). Abnormal electroretinogram and visual evoked cortical potential results indicated retinal and optic nerve dysfunction.
Area of Science:
- Ophthalmology
- Neuroscience
- Retinal Diseases
Background:
- Multiple evanescent white-dot syndrome (MEWDS) is an idiopathic inflammatory condition affecting the outer retina.
- Clinical presentation includes transient visual disturbances and characteristic fundus findings.
Observation:
- A 37-year-old female presented with acute visual symptoms and funduscopic evidence of MEWDS.
- Clinical examination revealed multiple white dots, macular granularity, and optic disc swelling.
Findings:
- Electrophysiologic tests, including electroretinogram (ERG) and electro-oculogram (EOG), indicated retinal pigment epithelium and photoreceptor dysfunction.
- Pattern-reversal visual evoked cortical potential (PVEP) showed prolonged P100 latency and reduced amplitude, alongside a relative afferent pupillary defect (RAPD) and enlarged blind spot, suggesting optic nerve involvement.
Implications:
- These findings underscore the potential for optic nerve dysfunction in MEWDS.
- Comprehensive electrophysiologic assessment is crucial for evaluating the extent of visual pathway involvement in MEWDS patients.