Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis.

B Falsini1, A Bardocci, S Cermola

  • 1Eye Clinic, Catholic University, Rome, Italy.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Autoantibodies detection in patients affected by autoimmune retinopathies.

European review for medical and pharmacological sciences·2024
Same author

Autoantibodies detection in patients affected by autoimmune retinopathies.

European review for medical and pharmacological sciences·2023
Same author

In Memory of Professor Derek Pheby.

La Clinica terapeutica·2023
Same author

Human Cloning: Biology, Ethics, and Social Implications.

La Clinica terapeutica·2023
Same author

Bioetics Issues of Artificial Placenta and Artificial Womb Technology.

La Clinica terapeutica·2023
Same author

Neurofibromatosis type 1-associated optic pathway gliomas: pathogenesis and emerging treatments.

European review for medical and pharmacological sciences·2023

Optic neuritis causes reduced pattern electroretinogram (PERG) amplitude, particularly at intermediate spatial frequencies. This suggests specific retinal neuron loss after optic neuritis.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Optic neuritis is an inflammatory condition affecting the optic nerve.
  • Pattern electroretinograms (PERGs) assess retinal ganglion cell function.
  • Spatial frequency perception is crucial for visual acuity.

Purpose of the Study:

  • To investigate spatial frequency-dependent changes in PERG amplitude and phase after optic neuritis.
  • To compare PERG responses between patients with optic neuritis and healthy controls.

Main Methods:

  • Recorded steady-state (8-Hz) PERGs using counterphased sinusoidal gratings (0.6-4.8 c/deg).
  • Analyzed the second harmonic of the PERG response for amplitude and phase.
  • Included 23 eyes from 17 patients with optic neuritis and 21 age-matched controls.

Related Experiment Videos

Main Results:

  • Significantly reduced mean PERG amplitude in optic neuritis patients compared to controls.
  • Amplitude reductions were most pronounced at intermediate spatial frequencies (1-1.4 c/deg).
  • PERG amplitude vs. spatial frequency showed a low-pass, not band-pass, function in patients; no significant phase differences were found.

Conclusions:

  • Optic neuritis leads to spatial frequency-dependent deficits in PERG amplitude.
  • These findings suggest a selective loss of retinal neurons sensitive to intermediate spatial frequencies.
  • PERG analysis can reveal specific functional impairments following optic neuritis.