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Updated: Aug 14, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Triallelic patterns in STR loci used for paternity analysis: evidence for a duplication in chromosome 2 containing
Matti Lukka1, Gunnar Tasa, Pekka Ellonen
1Paternity Testing Laboratory, Department of Molecular Medicine, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.
Abstract:
We report triallelic patterns in several short tandem repeat (STR) loci revealed by routine paternity testing using the commercial AMPFlSTR Profiler and AMPFlSTR SGMplus kits. One case where the TPOX-locus (2p25.3) produced three peaks from the blood sample of a child was analysed further. Quantitative polymerase chain reaction (QPCR) and STR typing of the DNAs of the family trio revealed a large (>1.59 Mb) duplication flanking the TPOX-locus in chromosome 2 in both the mother and child. The implications of such genetic anomalies for paternity testing are discussed.
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