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Updated: Aug 14, 2026

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice
Published on: July 11, 2016
Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse
Marion Espeli1, Benjamin Rossi, Stéphane J C Mancini
1Centre d'Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-University Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.
Abstract:
B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and mouse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition, the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and galectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed on the bases of the differences reported for pre-BCR and IL7 dependencies in the two species.
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