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Related Experiment Videos

Synaptic dynamics do not determine proper phase of activity in a central pattern generator.

Pascale Rabbah1, Farzan Nadim

  • 1Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 13, 2005
PubMed
Summary

Neuronal network activity relies on precise timing. In lobsters, the distinct intrinsic properties of neurons, not synaptic inputs, dictate their rhythmic activity phases.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Rhythmic motor activity depends on precise neuronal sequencing.
  • Neuronal networks achieve distinct activity phases through intrinsic properties and synaptic dynamics.
  • The pyloric network in lobsters is a model for studying rhythmic motor control.

Purpose of the Study:

  • To investigate the role of synaptic connections versus intrinsic neuronal properties in determining phase differences in the pyloric network.
  • To test the hypothesis that pacemaker-to-follower synapses dictate activity phases in the pyloric network.

Main Methods:

  • Characterized synaptic connections from the pacemaker ensemble to lateral pyloric (LP) and pyloric constrictor (PY) neurons.
  • Blocked chemical synapses and used dynamic-clamp to deliver identical artificial synaptic currents to LP and PY neurons.

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  • Analyzed phase relationships between LP and PY neurons under different conditions.

    • Main Results:

    • Synapses from the pacemaker ensemble to LP and PY neurons showed no significant differences in strength or short-term depression.
    • LP and PY neurons maintained their proper relative activity phase even when driven by identical artificial synaptic inputs.
    • Blocking chemical synapses did not alter the inherent phase differences between LP and PY neurons.

    Conclusions:

    • The relative phase of activity between LP and PY neurons in the pyloric network is determined by their intrinsic properties.
    • Synaptic inputs from the pacemaker ensemble do not dictate the phase relationships of these follower neurons.
    • Intrinsic neuronal properties are the primary drivers of rhythmic phase coordination in this neural circuit.