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Can a single, early quantitative human chorionic gonadotropin measurement in an in vitro fertilization-gamete
J S Heiner1, J F Kerin, L L Schmidt
1University of California-Los Angeles (UCLA), School of Medicine.
Study Objective:
To assess the predictive value of a single serum human chorionic gonadotropin (hCG) measurement obtained on day 14, 15, or 16 after transfer in in vitro fertilization or gamete intrafallopian transfer pregnancies.
Design:
Retrospective.
Setting:
Assisted reproductive technology (ART) programs.
Patients:
One hundred thirty-four consecutive pregnancies from two ART programs were reviewed.
Results:
The incidence of livebirth was only 6% when day 14 to 16 hCG values were less than 100 mIU/mL, but increased to 82% with levels greater than 100 mIU/mL (P less than 0.001). The incidence of livebirth and multiple birth correlated with rising hCG levels. Only 1% (1/71) of pregnancies with serum hCG values greater than 100 mIU/mL was ectopic, and this case was a bilateral (double) ectopic.
Conclusions:
A single serum hCG measurement obtained 14 to 16 days after embryo or gamete transfer not only is diagnostic but also has good predictive value for pregnancy outcome.
