Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MagScrew TAH: an update.

Stephan Weber1, Keiji Kamohara, Ryan S Klatte

  • 1The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. webers2@ccf.org

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What Makes a Great Manuscript?

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

ALK-Positive Lung Adenocarcinoma With Suspected Transformation to Squamous Cell Carcinoma in Lymph Node Metastases.

Annals of thoracic surgery short reports·2026
Same author

Successful orthotopic heart transplantation following total aortic replacement in a patient with Marfan syndrome: case report.

General thoracic and cardiovascular surgery cases·2026
Same author

Impact of osteoporosis on survival and aneurysm remodeling after endovascular aortic repair.

Vascular medicine (London, England)·2026
Same author

Combined Aspirin Study for Mechanical Prosthetic Valve in Kyushu and Ryukyu by Inter-University Hospital Network (ASPIRIN-Trial).

Circulation journal : official journal of the Japanese Circulation Society·2026
Same author

Innominate Artery Transection via Combined Suprasternal and Intercostal Approach Prevents Tracheoinnominate Artery Fistula.

Annals of vascular diseases·2026
Same journal

The HELP Score in Non-Asphyxial Hypothermic Cardiac Arrest Treated With Extracorporeal Life Support: External Validation and Clinical Utility.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Incidence and Mortality Outcomes of Extracorporeal Membrane Oxygenation in Infants With Congenital Lung Malformations: A Registry Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Hemolysis During Microaxial Flow Pump Support: Cause or Marker of Hemocompatibility-Related Adverse Events After Left Ventricular Assist Device Implantation?

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Machine Learning Prediction of Pediatric In-Hospital Survival Before Extracorporeal Membrane Oxygenation Cannulation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Erratum: Safety and Efficacy of Stored Wet-Preprimed Extracorporeal Membrane Oxygenation Circuits: A Scoping Review.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Case Series of Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiopulmonary Arrest After Cardiac Surgery.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
See all related articles

The MagScrew Total Artificial Heart (TAH) system shows promising results in early testing. This innovative device demonstrated excellent performance and biocompatibility in vivo, suggesting potential for future heart failure treatment.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Artificial Organs

Background:

  • Total Artificial Heart (TAH) systems are crucial for end-stage heart failure.
  • Developing reliable and biocompatible TAH systems remains a significant challenge.
  • The MagScrew TAH system represents a collaborative effort to advance TAH technology.

Purpose of the Study:

  • To characterize the performance and durability of the MagScrew Total Artificial Heart (TAH) system.
  • To evaluate the biocompatibility of the MagScrew TAH system under physiological conditions.
  • To assess the hydraulic pump performance and atrial balance of the TAH system.

Main Methods:

  • In vitro testing for system characterization and durability.
  • In vivo testing to evaluate performance and biocompatibility.

Related Experiment Videos

  • Utilizing a left master alternate left and right ejection control mode with Starling law-like response.

    • Main Results:

    • Excellent hydraulic pump performance with high device output (>9 L/min) at low left atrial pressures (<12 mm Hg).
    • Well-maintained atrial balance under all tested conditions.
    • Good biocompatibility demonstrated in vivo without anticoagulant therapy, with no thromboembolic events or tissue damage observed.

    Conclusions:

    • The MagScrew TAH system exhibits excellent hydraulic performance and biocompatibility.
    • In vivo results indicate a low risk of thromboembolic events and tissue damage.
    • The MagScrew TAH system shows potential as a viable option for patients with end-stage heart failure.