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Venlafaxine and bladder function.

Maurizio Inghilleri1, A Conte, V Frasca

  • 1Department of Neurological Sciences, University of Rome La Sapienza, Viale dell'Università 30, 00185 Rome, Italy. maurizio.inghilleri@uniroma1.it

Clinical Neuropharmacology
|December 13, 2005
PubMed
Summary
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Venlafaxine, an antidepressant, may improve urinary retention in patients with spinal cord injuries. This study found venlafaxine significantly reduced residual urine volume and increased urination frequency.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Urology

Background:

  • Selective serotonin and norepinephrine reuptake inhibitors (SSRIs), like venlafaxine, have been occasionally linked to urinary incontinence.
  • This study explores the paradoxical effect of venlafaxine on urinary function.

Purpose of the Study:

  • To investigate venlafaxine's effect on urinary function in patients with spinal cord-lesion-induced urinary retention.
  • To determine if venlafaxine could be a treatment for urinary retention.

Main Methods:

  • A 1-week baseline assessment of postvoiding residual volume and micturition frequency.
  • Administration of venlafaxine 75 mg extended-release once daily for 1 week.

Main Results:

  • Venlafaxine (75 mg/day) significantly reduced postvoiding residual urine volume.

Related Experiment Videos

  • Micturition rate increased significantly with venlafaxine treatment.
  • No severe side effects were reported by patients.

    • Conclusions:

    • Venlafaxine shows potential as a treatment to improve bladder voiding in patients with spinal cord disease.
    • Further research is warranted to confirm venlafaxine's efficacy and safety in managing urinary retention.