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Updated: Aug 14, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Acute central serous chorioretinopathy and fundus autofluorescence
Chiara M Eandi1, Michael Ober, Reza Iranmanesh
1The LuEsther T. Mertz Retina Research Center of Manhattan Eye, Ear and Throat Hospital, New York, NY 10021, USA.
Objectives:
To describe fundus autofluorescence (FAF) in a series of patients with acute central serous chorioretinopathy (CSC).
Methods:
Nine eyes of six patients with acute CSC were evaluated with fluorescein angiography (FA) and FAF imaging to evaluate the nature of the focal retinal pigment epithelial (RPE) leak evident with FA.
Results:
All nine eyes in this series demonstrated hypo-autofluorescence corresponding precisely to the site of the focal RPE leak seen on FA.
Conclusions:
In this group of patients, the acute focal RPE leaks seen with FA corresponded precisely to an area of hypo-autofluorescence imaged with FAF. This observation supports the concept that a mechanical defect or absence of the RPE accounts for the leakage from the inner choroid to the sub-neurosensory space in CSC. FAF is also a useful noninvasive diagnostic adjunct to identify the focal RPE leak in patients with acute CSC.
