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Updated: Aug 14, 2026
07:54
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
[Mesothelioma: advances in chemotherapy]
1Service de Pneumologie, CHU, Besançon, France. pascale.jacoulet@ufc-chu.univ-fcomte.fr
Revue Des Maladies Respiratoires
|December 13, 2005
Summary
For mesothelioma, cisplatin and pemetrexed chemotherapy is a primary treatment. Promising alternatives include antimetabolites and vinca alkaloids, showing about 50% one-year survival in recent studies.
Area of Science:
- Oncology
- Medical Chemistry
Context:
- Mesothelioma treatment often relies on chemotherapy for advanced or metastatic stages.
- Pemetrexed gained license for mesothelioma treatment in September 2004.
Purpose:
- To review chemotherapy drugs and targeted therapies for mesothelioma.
- To evaluate recent studies on treatment efficacy.
Summary:
- Cisplatin and pemetrexed combination is recommended first-line therapy.
- Vinca alkaloids (vinorelbine, vinflunine) and antimetabolites (gemcitabine, raltitrexed, pemetrexed) show promise.
- Combinations of antimetabolites and platinum salts yield approximately 50% one-year survival.
Impact:
- Identifies effective chemotherapy agents and combinations for mesothelioma.
- Highlights promising treatments for patients ineligible for clinical trials.
- Provides an overview of ongoing targeted therapy research.
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