Related Experiment Video

Updated: Aug 14, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Recommended antimicrobial agents for the treatment and postexposure prophylaxis of pertussis: 2005 CDC Guidelines

Tejpratap Tiwari, Trudy V Murphy, John Moran

    MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports
    |December 13, 2005
    PubMed

    Insights

    This report updates pertussis (whooping cough) treatment guidelines, expanding antimicrobial options beyond erythromycin. New recommendations cover azithromycin and clarithromycin dosing for effective pertussis management and prophylaxis.

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Pharmacology

    Background:

    • Pertussis, or whooping cough, remains a significant public health concern.
    • Erythromycin has been a primary treatment, but concerns about resistance and side effects exist.
    • Broader antimicrobial options are needed for effective treatment and postexposure prophylaxis.

    Purpose of the Study:

    • To broaden the spectrum of available antimicrobial agents for pertussis treatment.
    • To provide updated recommendations for macrolide agents other than erythromycin.
    • To detail the dosing schedules for azithromycin and clarithromycin by age group.

    Main Methods:

    • Review and synthesis of existing literature on pertussis treatment and prophylaxis.
    • Analysis of antimicrobial spectrum and efficacy data for macrolide agents.
    • Development of age-specific dosing recommendations for azithromycin and clarithromycin.

    Main Results:

    • Updated recommendations include azithromycin and clarithromycin as viable alternatives to erythromycin.
    • Specific dosing schedules for azithromycin and clarithromycin are provided for different age groups.
    • These macrolide agents offer a broader spectrum for pertussis management.

    Conclusions:

    • Expanded antimicrobial choices improve pertussis treatment and prophylaxis strategies.
    • Azithromycin and clarithromycin provide effective options with defined dosing.
    • Updated guidelines enhance public health preparedness against pertussis.

    More Related Videos

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

    Published on: January 2, 2017

    Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens13:47

    Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

    Published on: May 19, 2020

    Related Concept Videos

    Transmission-based Precautions II: Airborne and Protective Environment01:25

    Transmission-based Precautions II: Airborne and Protective Environment

    Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
    Airborne precautions:
    Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
    Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

    Transmission-based Precautions I: Contact, Enteric, and Droplets

    Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
    Contact Precautions:
    Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
    Pulmonary Tuberculosis V01:28

    Pulmonary Tuberculosis V

    Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
    Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
    Smallpox01:24

    Smallpox

    Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
    Pneumonia IV: Management01:28

    Pneumonia IV: Management

    The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
    Bacterial Pneumonia Treatment
    For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
    Pneumonia V: Nursing management and Prevention01:30

    Pneumonia V: Nursing management and Prevention

    Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
    The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
    Enhance airway patency
    Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.