[Pregnancy onset without corpus luteum function?]

Within five years, a patient had five abortions and one biochemical pregnancy with two different partners. After the fourth pregnancy, she underwent a heterologous immune stimulation. The karyotypes of all three partners were normal. On her first visit, a subclinical hypothyroidism was detected and substitution with 50 micrograms L-thyroxine was started. Before further endocrinological, virological, or anatomical investigation, the patient conceived spontaneously for the seventh time. Even though the beta-HCG-levels rose adequately and the sonographic development was according to time, serum-progesterone could not be detected before the eighth week of pregnancy and sufficient levels were found from the 15th week onwards. The patient received a hormonal substitution therapy with Gravibinon 250 mg i.m. twice a week up to the 15th week of gestation. She finally delivered a 3800 g healthy boy.