Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dectin-1: a signalling non-TLR pattern-recognition receptor.

Gordon D Brown1

  • 1Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa. gordon.brown@mweb.co.za

Nature Reviews. Immunology
|December 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The prebiotic inulin affects virulence factor expression in <i>Candida albicans</i>.

mBio·2026
Same author

Short-term antagonism between bacteriophages and macrophages decreases with bacteria-phage coevolution.

The ISME journal·2026
Same author

Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival.

Science immunology·2026
Same author

Working together to tackle fungal disease across Latin America.

Trends in microbiology·2025
Same author

PTP1B deficiency in myeloid cells increases susceptibility to <i>Candida albicans</i> systemic infection by modulating antifungal immunity.

mBio·2025
Same author

Effects of Short-Chain Fatty Acid Combinations Relevant to the Healthy and Dysbiotic Gut upon Candida albicans.

Current microbiology·2025
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
Same journal

Programming the immunological properties of mRNA vaccines for cancer.

Nature reviews. Immunology·2026
Same journal

Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.

Nature reviews. Immunology·2026
Same journal

Hallmarks and correlates of effective adoptive cell immunotherapy for cancer.

Nature reviews. Immunology·2026
Same journal

The immunology of human breast cancer.

Nature reviews. Immunology·2026
See all related articles

Dectin-1, a key innate immune receptor, binds fungi and triggers cellular responses. Its signaling pathways, including collaboration with Toll-like receptors (TLRs) and spleen tyrosine kinase (SYK), are crucial for immunity and may influence autoimmune diseases.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Dectin-1 is a C-type lectin receptor involved in innate immunity against fungal pathogens.
  • It mediates fungal binding, uptake, killing, and cytokine/chemokine production.
  • Dysregulation of Dectin-1 signaling may contribute to autoimmunity and disease.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying Dectin-1's cellular functions.
  • To explore the collaborative signaling between Dectin-1 and Toll-like receptors (TLRs).
  • To highlight the role of spleen tyrosine kinase (SYK) in Dectin-1-mediated signaling.

Main Methods:

  • Review of existing literature on Dectin-1 function and signaling pathways.
  • Analysis of molecular interactions and cellular responses mediated by Dectin-1.

Related Experiment Videos

  • Discussion of implications for non-TLR pattern-recognition receptor (PRR) roles in immunity.

    • Main Results:

    • Dectin-1 mediates critical functions in fungal recognition and clearance.
    • Collaborative signaling between Dectin-1 and TLRs enhances immune responses.
    • Spleen tyrosine kinase (SYK) is a key mediator of Dectin-1 signaling.

    Conclusions:

    • Understanding Dectin-1's molecular mechanisms provides insights into innate immunity.
    • Dectin-1's interactions with TLRs and SYK are vital for effective immune responses.
    • These findings have broader implications for the role of PRRs in immunity and disease.