Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyelectrolyte multilayers and degradable polymer layers as multicompartment films.

Juan Méndez Garza1, Nadia Jessel, Guy Ladam

  • 1INSERM U595, Strasbourg, F-67085, and Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg, F-67085 France.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 14, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and validation of a bioactive and antimicrobial coating through advanced deposition strategies for biomedical applications.

Biomaterials science·2026
Same author

Shaking things up: exploiting the potential of mechanochemistry to enhance deracemization of racemic compounds.

Chemical communications (Cambridge, England)·2026
Same author

Physiological metal-based nanoparticles as bioactive agents for antimicrobial activity and wound repair: Strategies for hydrogel-mediated delivery.

Acta biomaterialia·2026
Same author

A proof-of-concept study of an albumin-based bilayered scaffold for cartilage regeneration.

Materials today. Bio·2026
Same author

Natural antimicrobial polymeric coatings for contamination resistant wound dressings: biocompatibility and <i>in vivo</i> efficacy against MRSA.

Journal of materials chemistry. B·2026
Same author

Lattice softening and diffusive dynamics in the polar metal LiReO<sub>3</sub>.

Science advances·2026

Biodegradable polymer barriers combined with polyelectrolyte multilayers offer controlled cell activity. These novel biomaterial coatings release encapsulated molecules over time, enabling timed biological responses.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cell Biology

Background:

  • Polyelectrolyte multilayers (PEMs) are established biomaterial coatings.
  • Controlling cellular activity with multicompartment films is a novel approach.
  • Previous work utilized non-degradable synthetic polyelectrolyte barriers.

Purpose of the Study:

  • To develop and evaluate biodegradable barriers for PEMs.
  • To create multicompartment films with tunable drug/molecule release.
  • To investigate timed cellular responses to controlled molecular release.

Main Methods:

  • Alternating deposition of poly(L-lysine)/hyaluronic acid (PLL/HA) reservoirs and poly(lactic-co-glycolic acid) (PLGA) barriers.
  • Fabrication of PEM/hydrolyzable polymeric layer films.

Related Experiment Videos

  • Seeding bone marrow cells on fabricated films and monitoring degradation and internalization.

    • Main Results:

    • Successfully fabricated PEM/PLGA films acting as reservoirs/barriers.
    • Bone marrow cells degraded the outer PLL/HA reservoir and internalized PLL.
    • Cells subsequently degraded the PLGA barrier, accessing and internalizing PLL from a lower compartment after 5 days.

    Conclusions:

    • Biodegradable PLGA barriers enable timed release from PEM reservoirs.
    • Mixed architectures of PEMs and hydrolyzable polymers can induce scheduled biological activities.
    • Tunable degradation of PLGA barriers allows control over release kinetics for biomaterial coatings.