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Tisseel and its effects on wound drainage post-thyroidectomy: prospective, randomized, blinded, controlled study
Trina C Uwiera1, Richard R E Uwiera, Hadi Seikaly
1Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB.
The Journal of Otolaryngology
|December 14, 2005
Summary
Fibrin sealant significantly reduced wound drainage after thyroidectomy, decreasing output by 44% in the first 8 hours and 43% overall. This suggests fibrin sealants may enable drain-free thyroidectomy procedures.
Area of Science:
- Surgical Innovation
- Biomaterials in Medicine
- Endocrine Surgery
Background:
- Thyroidectomy is a common surgical procedure.
- Postoperative wound drainage is a frequent complication.
- Minimizing wound drainage can improve patient outcomes and potentially reduce hospital stay.
Purpose of the Study:
- To evaluate the efficacy of fibrin sealant (Tisseel) in reducing wound drainage after thyroidectomy.
- To assess the safety and impact of fibrin sealant on drain removal and complications.
Main Methods:
- A randomized, blinded, controlled study involving 56 patients undergoing thyroidectomy.
- Patients were allocated to either fibrin sealant (Tisseel) or no-treatment groups.
- Wound drain output was meticulously recorded by blinded observers in 8-hour intervals.
Main Results:
- Fibrin sealant significantly decreased wound drainage within the first 8 hours post-surgery.
- A 44% reduction in wound output was observed at 8 hours in the Tisseel group compared to controls.
- Overall drainage over 64 hours was reduced by 43%, with a trend towards earlier drain removal without increased complications.
Conclusions:
- Fibrin sealants (Tisseel) are effective in safely reducing post-thyroidectomy wound drainage.
- The findings support the potential implementation of drain-free thyroidectomy procedures using fibrin sealants.