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Novel derivatives of chitosan and their antifungal activities in vitro

Zhanyong Guo1, Rong Chen, Ronge Xing

  • 1Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. guozhanyong@ms.qdio.ac.cn

Carbohydrate Research
|December 14, 2005
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...