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Updated: Aug 14, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Kinetic and safety assessment for salicylic acid nitration by nitric acid/acetic acid system
R Andreozzi1, V Caprio, I Di Somma
1Università di Napoli Federico II, p.le V. Tecchio, 80-80125 Napoli, Italy. roberto.andreozzi@unina.it
Abstract:
The nitration process of salicylic acid for the production of the important intermediate 5-nitrosalicylic acid is studied from thermokinetic and safety points of view. Investigations carried out by considering, as process deviations, the loss of the thermal control point out the possibility of runaway phenomena due to the occurrence of polynitration reactions. Isothermal experiments are carried out in various conditions to assess the involved reaction network and reaction kinetics.
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